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Jenny: Welcome to today's episode of Myeloma Crowd Radio, a show that connects patients with myeloma researchers. I'm your host, Jenny Ahlstrom, and I'm joined today by my myeloma friends including Pat Killingsworth, Gary Peterson, Cynthia Chmielewski, and Jack Aiello as co-hosts. This is the fourth and a very important series featuring the Myeloma Crowd Research Initiative. For the first time, patients, including you, are teaming up with myeloma researchers to find and fund the ideas in myeloma that could have the greatest impact for the next generation of myeloma therapies. We decided to go after high-risk myeloma for patients that have no viable options today either because they have high-risk features or relapsing or refractory to existing drugs. We need new options and if we can find a solution for high-risk patients, it's highly likely that it'll work in medium or low-risk patients. It's also common to pick up more aggressive genetic features as the disease progresses. Unfortunately, many of us become high-risk after our myeloma has relapsed multiple times or current medications become ineffective. We're now in stage three of the Myeloma Crowd Research Initiative or we call it the MCRI. In stage 1, we asked researchers around the world to submit their proposals and we received back 36 high-quality letters of intent. In stage 2, we have those proposals scored by our Scientific Advisory Board. They selected ten proposals, which they believed were the top proposals, and we are now holding Myeloma Crowd Radio shows so that you can become involved. We want you to understand the proposals, so please listen in, ask questions, read the transcript after the show is posted, and share it with your friends and family. After the full proposals are submitted, the Scientific Advisory Board and Myeloma Patient Advisory Board will together decide on a limited number to fund through patient-driven campaigns, and we will need your help to get the word out and share the very amazing work that's being done.

Finally, Rainbow Rentals is on the west coast of the Island and consists of five colorful huts on the beach. You can easily rotate there from Holly Hedges since it’s directly southwest of that area.

Apex Legends had its two-year anniversary this year, as well as celebrating cem million players. Although the game is doing extremely well and is constantly growing, with the release of next generation consoles, when will we be seeing an upgraded version of the free-to-play battle royale?

Excel e outro de informatica. eu queria saber qual é O MAIS EFICAZ produção de modo a mim qual nãeste tem muita experiencia e nunca trabalhou.

It is our opinion that again -- and perhaps coming back from where we started with this radio show, I think the time has come to really improve the response criteria and the biology regarding response criteria in the same level as the essential diagnoses, risk stratification, and treatment options that have been improved in the last five to ten years.

If he’s going to take his sound city and statewide, he’s going to need some help getting started. Keep an eye out for opportunities to support your local disc-jockey on December 15th."

Dr. Paiva: Absolutely, plus it's really an imagined field, which is quite conterraneo. In fact, the implementation of new biomarkers takes several years. If we look, for example, to other diseases such as acute leukemia, the concept of MRD, which is now fully established, took a long time. In multiple myeloma, unfortunately until five or ten years ago, there weren't many therapeutic options. The options available were not tremendously effective and therefore, complete remissions were rather scanty. Only a few patients achieved deep levels of remission. Consequently, also survival was limited at the time. Nowadays, as we are probably all aware, there are many more very effective options to treat multiple myeloma. We've produced nowadays a much higher rate of complete response, which for both younger transplant patients as well as for elderly check here non-transplant candidates are now in the range of 50%. Therefore, you can see the dramatic evolution and the fortunate evolution on the treatment of the disease. We can also see a dramatic evolution in our understanding of the biology of the myeloma plasma cell, also the biology of normal cells, for example, the chemo-resistant stem cells.

After more than 20 years, Square Enix’s SaGa Frontier has received a remaster. Does this JRPG hold up to today’s standards, or should you stick to some of the more modern players in the space?…

We also see a great improvement in patient's differential diagnoses. We now have better tools to differentiate between treatments requiring myeloma, ultra high-risk myeloma, smoldering myeloma, high-risk smoldering myeloma, MGUS, also better tools to predict the risk of a newly diagnosed myeloma patient, discriminating between those with standard versus high-risk disease. But in contrast and for many years now, there has been pelo evolution in how we measure response to therapy. While before there was really no rationale to improve the sensitivity of the techniques used to monitor this costly therapy, nowadays given the efficacy of the novel agents and more complex treatment schemas, it becomes mandatory to measure a response to therapy using very sensitive tools in order to understand and to identify those patients that are truly responding to chemotherapy and achieve deep levels of remission than those patients which are more chemo-resistant. The identification of both will be crucial as we move along into precision medicine and we'll try to avoid both the under as well as over-treatment. Here lies the importance of minimal residual disease.

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Landgren and he was saying how it will tailor treatment and allow more of the precision medicine to say, "Okay, if you haven't responded, this is why," and then you can customize treatment for different individuals.

Эх, воспоминания. Ну, сейчас дело другое. И даже место прямо-таки противоположное: вместо заснеженной тихой глубинки нам откроется настоящий остров вечеринок.

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Dr. Paiva, we've kept you way over time today, but we think it's worth it, so we're so thankful for your participation today. Thank you for all you're doing.

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